The Vanpouille-Box Lab

08/13/21

The main focus of our group is to investigate the key factors impacting the immunogenicity of radiotherapy in brain malignancies. More specifically, the Vanpouille-Box lab aims at exploring the immune-metabolic role of radiation therapy and to define the impact of TGFb and activin A in the radiation response of glioblastomas.

With a better understanding of the metabolic changes, molecular pathways and cellular responses from the host and/or the tumor that result from radiation therapy, our main goal is to identify new actionable targets for the modulation of anti-tumor immune responses against glioblastomas.

Members:

Claire Vanpouille-Box, PhD

Assistant Professor

clv2002@med.cornell.edu

Claire Vanpouille-Box is an Assistant Professor of Cell Biology in Radiation Oncology. She developed a keen interest in anti-cancer treatments based on the combination of immunotherapy and radiation therapy (RT). Her graduate work at the University of Angers (France), studied a new treatment concept that aims at generating a localized RT via the use of nanoparticles during which she became interested in radiation-induced anti-tumor immunity.

She then conducted her postdoctoral training  at NYU School of Medicine and at Weill Cornell Medicine whose preclinical studies demonstrated that TGFb is a master regulator of RT-induced anti-tumor immunity and that RT-induced cancer-cell type I interferon is required to elicit durable regression of the irradiated and non-irradiated tumor (i.e., the abscopal effect).

Claire has received many prestigious awards among which the 2014-Marie Curie Award from the Radiation Research Society (RRS) and the 2015-AACR Susan G Komen Scholar-in-training award from the American Association for Cancer Research (AACR).

She serves as an associate editor for the Journal of Translational Medicine and Radiation Research.

Mara De Martino, PhD

Post-Doctoral Associate

mde4002@med.cornell.edu

Mara obtained her PhD degree in tumor immunology at Buenos Aires University, Argentina. Her research interests are largely direct towards understanding how tumors interact with the immune system in order to develop effective immunotherapies against cancer. Mara joined the laboratory of Dr. Vanpouille-Box as a Postdoctoral Associate in August, 2019. Her current research interest is focused on the impact of radiotherapy in the tumor microenvironment and the immunogenicity of glioblastoma. During her free time, Mara enjoys hanging out with friends and family.

Camille Daviaud

Research Technician

cad2038@med.cornell.edu

Camille obtained her “Licence professionnelle” (equivalent of B.S.) in Analytical and Experimental Biology at the University of Angers, France. She has many years of experience working on the immunogenic effect of radiation therapy in cancer. As a research technician in the Vanpouille-Box laboratory, she brings her managerial and technical skills for the studying of key factors impacting the immunogenicity of radiotherapy in glioblastomas. Outside of work Camille enjoys creative activities such as drawing or photography and spending time in Central park strolling and watching birds.

Recent Publications

• De Martino M, Daviaud C, Diamond JM, Kraynak J, Alard A, Formenti SC, Miller LD, Demaria S, Vanpouille-Box C.Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer. Cancer Immunol Res. 2020 Oct 22. doi: 10.1158/2326-6066.CIR-19-0305. Online ahead of print.PMID: 33093219
• De Martino M, Vanpouille-Box C. Apoptotic Caspases: A Double-Edged Sword in Radiation-Induced Immunogenicity. Trends Cell Biol. 2019 Nov;29(11):851-853. doi: 10.1016/j.tcb.2019.09.001. Epub 2019 Oct 14.PMID: 31623928
• Vanpouille-Box C, Hoffmann JA, Galluzzi L. Pharmacological modulation of nucleic acid sensors – therapeutic potential and persisting obstacles. Nat Rev Drug Discov. 2019 Nov;18(11):845-867. doi: 10.1038/s41573-019-0043-2. Epub 2019 Sep 25.PMID: 31554927 Review.

For a complete list, please visit here: https://www.ncbi.nlm.nih.gov/myncbi/claire.vanpouille-box.1/bibliography/public/