Radiation Oncology

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The Vanpouille-Box Lab

1/16/20

The main focus of our group is to investigate the key factors impacting the immunogenicity of radiotherapy in brain malignancies. More specifically, the Vanpouille-Box lab aims at exploring the immune-metabolic role of radiation therapy and to define the impact of TGFb and activin A in the radiation response of glioblastomas.

With a better understanding of the metabolic changes, molecular pathways and cellular responses from the host and/or the tumor that result from radiation therapy, our main goal is to identify new actionable targets for the modulation of anti-tumor immune responses against glioblastomas.

Members:

Claire Vanpouille Box

Claire Vanpouille-Box, PhD

Assistant Professor

clv2002@med.cornell.edu

Claire Vanpouille-Box is an Assistant Professor of Cell Biology in Radiation Oncology. She developed a keen interest in anti-cancer treatments based on the combination of immunotherapy and radiation therapy (RT). Her graduate work at the University of Angers (France), studied a new treatment concept that aims at generating a localized RT via the use of nanoparticles during which she became interested in radiation-induced anti-tumor immunity.

She then conducted her postdoctoral training  at NYU School of Medicine and at Weill Cornell Medicine whose preclinical studies demonstrated that TGFb is a master regulator of RT-induced anti-tumor immunity and that RT-induced cancer-cell type I interferon is required to elicit durable regression of the irradiated and non-irradiated tumor (i.e., the abscopal effect).

Claire has received many prestigious awards among which the 2014-Marie Curie Award from the Radiation Research Society (RRS) and the 2015-AACR Susan G Komen Scholar-in-training award from the American Association for Cancer Research (AACR).

She serves as an associate editor for the Journal of Translational Medicine and Radiation Research.

maria_demartino

Mara De Martino, PhD

Post-Doctoral Associate

mde4002@med.cornell.edu

Mara obtained her PhD degree in tumor immunology at Buenos Aires University, Argentina. Her research interests are largely direct towards understanding how tumors interact with the immune system in order to develop effective immunotherapies against cancer. Mara joined the laboratory of Dr. Vanpouille-Box as a Postdoctoral Associate in August, 2019. Her current research interest is focused on the impact of radiotherapy in the tumor microenvironment and the immunogenicity of glioblastoma. During her free time, Mara enjoys hanging out with friends and family.

camille_daviaud

Camille Daviaud

Research Technician

cad2038@med.cornell.edu

Camille obtained her “Licence professionnelle” (equivalent of B.S.) in Analytical and Experimental Biology at the University of Angers, France. She has many years of experience working on the immunogenic effect of radiation therapy in cancer. As a research technician in the Vanpouille-Box laboratory, she brings her managerial and technical skills for the studying of key factors impacting the immunogenicity of radiotherapy in glioblastomas. Outside of work Camille enjoys creative activities such as drawing or photography and spending time in Central park strolling and watching birds.

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Contact Us

David H. Koch Center

New York-Presbyterian Hospital/
Weill Cornell Medical Center
1283 York Avenue, 4th floor
New York, NY 10065
Tel: (212) 746-3600
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Stich Radiation Oncology Center

New York-Presbyterian Hospital/
Weill Cornell Medical Center
525 East 68th Street
New York, NY 10065
Tel: (212) 746-3600
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The Arnold Center For Radiation Oncology

New York Hospital Queens
56-45 Main Street
(56th Avenue between Main Street and 141st Street)
Flushing, NY 11355
Tel: (718) 670-1501

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New York-Presbyterian/
Lower Manhattan Cancer Center

21 West Broadway
New York, NY 10003
Tel: (212) 746-6600

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