Radiation Oncology

You are here

The Demaria Lab

The Demaria’s lab has a central interest in addressing the molecular mechanisms whereby ionizing radiation modulates tumor immunogenicity, and exploiting this property of radiation to achieve a therapeutic synergy with immunotherapy in pre-clinical tumor models and in cancer patients. We have recently demonstrated that an enzyme called TREX1 and implicated in autoimmune diseases and viral infections also regulates radiation therapy’s ability to trigger an immune response against the cancer. TREX1 regulates the levels of DNA displaced to the cytosol as a consequence of radiation-induced DNA damage, hindering the activation of type I interferon via the cGAS/STING pathway. Thus, we are currently investigating which pathways link DNA damage repair to innate immune sensing and activation of adaptive anti-tumor immunity in the context of cancer. In addition, we have recently identified mutation-generated CD8 T cell epitopes that are selectively exposed in irradiated cancer cells and we are currently determining their contribution to immune-mediated rejection of irradiated and non-irradiated tumors.


Sandra Demaria, MD

Principal Investigator


Sandra Demaria, M.D., a native of Turin, Italy, obtained her M.D. from the University of Turin, and then moved to New York for her post-doctoral training in immunology as a Damon Runyon-Walter Winchell Cancer Research Fund awardee, followed by a residency in anatomic pathology at NYU School of Medicine (NYU SoM). She remained on the faculty at NYU SoM until 2015 raising to the rank of Professor. She is currently Professor of Radiation Oncology and Pathology at Weill Cornell Medicine in New York City. Dr. Demaria is internationally known for her studies demonstrating the synergy of local radiation therapy with different immunotherapeutic agents in pre-clinical models of cancer. She was the first to show that radiotherapy can convert tumors unresponsive to immune checkpoint inhibitors into responsive ones, a finding being translated in several clinical trials at multiple institutions. As a breast cancer pathologist Dr. Demaria has also studied the immunological microenvironment of breast cancer in patients, and therapeutic strategies to modulate the immune infiltrate in preclinical breast cancer models. Her current work is funded by the US National Cancer Institute and by several private foundations. She has held leadership positions in national professional societies, including the Society for Immunotherapy of Cancer (SITC) where she served on the Board, the AACR Cancer Immunology Working Group Steering Committee, and the Radiation Research Society. She serves in the editorial board of several journals, including The Journal of Immunology, Clinical Cancer Research, and Journal for ImmunoTherapy of Cancer. 

Erik Wennerberg, PhD

Post-Doctoral Fellow


Claire Lhuillier, PhD

Post-Doctoral Fellow


Nils-Petter Rudqvist, Ph.D.

Post-Doctoral Fellow


Sheila Spada, Ph.D.

Post-Doctoral Fellow


Yasmeen Sarfraz, M.S.

Lab Manager



Maud Charpentier, Ph.D.

Post-Doctoral Fellow


Dr van nest photo

Samantha Van Nest, Ph.D.

Post-Doctoral Fellow


Samantha obtained her PhD in Medical Physics at the University of Victoria on Vancouver Island, Canada. Her research interests include developing techniques for the personalization of radiation therapy including spectroscopic and sequencing approaches. As a Postdoctoral Associate with Dr. Demaria, her research investigates the use of  primary organoid models for optimizing radiation therapy  and immunotherapy combination treatments. She is also developing techniques to use exosome and extracellular vesicles to inform optimal radiation therapy doses for patient treatments. In her free time, you can find Samantha camping in the forests, kayaking, or caving throughout North America. 

Recent Publications 

  • Galluzzi L., Vanpouille-Box C., Bakhoum S.F. Demaria S. SnapShot: CGAS-STING signalingCell, 2018. 173(1): p. 276–276.e1. PMID: 29570996
  • Rudqvist NP, Pilones KA, Lhuillier C, Wennerberg E, Sidhom JW, Emerson RO, Robins HS, Schneck J, Formenti SC, Demaria S. Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells. Cancer Immunol Res. 2018 Feb;6(2):139-150. PMID: 29180535
  • Vanpouille-Box C, Formenti SC, Demaria S. Towards precision radiotherapy for use with immune checkpoint blockers. Clin Cancer Res 2018, 24(2):259-265. PMID: 28751442
  • Vanpouille-Box C, Alard A, Aryankalayil MJ, Sarfraz Y, Diamond JM, Schneider RJ, Inghirami G, Coleman CN, Formenti SC, Demaria S. DNA exonuclease Trex1 regulates radiotherapy-induced tumor immunogenicity. Nat Commun. 2017; 8:15618. PMID: 28598415
  • Wennerberg E, Lhuillier C, Vanpouille-Box C, Pilones KA, García-Martínez E, Rudqvist NP, Formenti SC, Demaria S. Barriers to radiation-induced in situ tumor vaccination. Front Immunol. 2017 Mar 13;8:229. PMID: 28348554
  • Dieci MV, Radosevic-Robin N, Fineberg S, van den Eynden G, Ternes N, Penault-Llorca F, Pruneri G, D'Alfonso TM, Demaria S, Castaneda C, Sanchez J, Badve S, Michiels S, Bossuyt V, Rojo F, Singh B, Nielsen T, Viale G, Kim SR, Hewitt S, Wienert S, Loibl S, Rimm D, Symmans F, Denkert C, Adams S, Loi S, Salgado R; International Immuno-Oncology Biomarker Working Group on Breast Cancer. Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Semin Cancer Biol. 2017; Oct 9. pii: S1044-579X(17)30217-1. doi: 10.1016/j.semcancer.2017.10.003. PMID: 29024776
  • Demaria S, Coleman CN, Formenti SC. Radiotherapy: Changing the Game in Immunotherapy. Trends in Cancer, 2016, 2(6):286-294. PMID: 26270858
  • Vanpouille-Box C., Diamond J.M., Pilones K.A., Zavadil J., Babb J.S., Formenti S.C., Barcellos-Hoff M-H., Demaria S. 2015. Transforming Growth Factor (TGF) β is a master regulator of radiotherapy-induced anti-tumor immunity. Cancer Res, 2015; 75 (11): 2232-42. PMID: 25858148
  • Demaria S., Golden E.B., Formenti S.C. 2015. The Role of Local Radiation Therapy in Cancer Immunotherapy. JAMA Oncol, 2015; 1(9):1325-32. PMID: 26270858

For a complete list of peer-reviewed publications from Sandra Demaria, please visit here.

Schedule Appointment

There are many ways to request for an appointment with us. Give us a call at the information below, login to your Weill Cornell Connect or fill out the online form.

Contact Us

David H. Koch Center

New York-Presbyterian Hospital/
Weill Cornell Medical Center
1283 York Avenue, 4th floor
New York, NY 10065
Tel: (212) 746-3600
View Map

Stich Radiation Oncology Center

New York-Presbyterian Hospital/
Weill Cornell Medical Center
525 East 68th Street
New York, NY 10065
Tel: (212) 746-3600
View Map

The Arnold Center For Radiation Oncology

New York Hospital Queens

56-45 Main Street
(56th Avenue between Main Street and 141st Street)
Flushing, NY 11355
Tel: (718) 670-1501

View Map

New York-Presbyterian/
Lower Manhattan Cancer Center

21 West Broadway
New York, NY 10003
Tel: (212) 746-6600

View Map