Radiation Oncology

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The Galluzzi Lab

10/30/19

The current interest of our team is to elucidate the links between cellular pathways of response to stress – including (but not limited to) autophagy, cellular senescence and multiple variants of regulated cell death – and the preservation of organismal homeostasis, with a particular focus on anticancer immunity. More specifically, we are interested in dissecting the complexity of the tumor microenvironment with respect to the mechanisms through which malignant as well as non-malignant components of the tumor exposed to chemotherapy, radiation therapy and immunotherapy emit danger signals that are involved in the initiation and perpetuation of robust immune responses. The detailed characterization of these molecular and cellular circuitries may identify stress-responsive mechanisms of adaptation in malignant or non-malignant cells as novel targets for the pharmacological manipulation of anticancer immune responses. Ultimately, these findings may translate into novel clinical studies based on combinatorial therapeutic regimens aimed at maximizing immunostimulation within the tumor microenvironment.

Members:

Lorenzo Galluzzi, PhD

Principal Investigator

log3001@med.cornell.edu

Lorenzo Galluzzi (born 1980) is currently Assistant Professor of Cell Biology in Radiation Oncology with the Department of Radiation Oncology of the Weill Cornell Medical College (New York, NY, USA), Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine (New Haven, CT, USA), Honorary Associate Professor with the Faculty of Medicine of the Paris Descartes University (Paris, France), and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara (Ferrara, Italy) and the Graduate School of Pharmacological Sciences of the University of Padova (Padova, Italy).

Prior to joining Weill Cornell Medical College (2017), Lorenzo Galluzzi was a Junior Scientist of the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2012-2016). Lorenzo Galluzzi did his post-doctoral training at the Gustave Roussy Comprehensive Cancer Center (Villejuif, France; 2009-2011), after receiving his PhD from the Paris Sud University (Le Kremlin-Bicetre, France; 2005-2008). He is also Associate Director of the European Academy for Tumor Immunology (EATI), and Founding Member of the European Research Institute for Integrated Cellular Pathology (ERI-ICP).

Lorenzo Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. In particular, he provided profound insights into the links between adaptive stress responses in cancer cells and the activation of a clinically relevant tumor-targeting immune response in the context of chemotherapy and radiation therapy. Lorenzo Galluzzi has published more than 440 scientific articles in international peer-reviewed journals. According to a survey published by Lab Times, he is currently the 6th and the youngest of the 30 most-cited European cell biologists (relative to the period 2007–2013), and he was nominated Highly Cited Researcher by Clarivate Analytics (formerly, Thomson Reuter) in 2016 and 2018.

Lorenzo Galluzzi currently operates as Editor-in-Chief of three journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, and Molecular and Cellular Oncology (which he co-founded in 2013). In addition, Lorenzo Galluzzi currently serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease and Aging.



Takahiro Yamakazi, PhD

Post-Doctoral Associate

tay2007@med.cornell.edu

Aitziber Buqué Martinez, PhD

Post-Doctoral Associate

abm2013@med.cornell.edu

Norma Bloy, PhD

Post-Doctoral Associate

nob4001@med.cornell.edu

Ai Sato

Research Specialist

ais2010@med.cornell.edu

  

Original Articles 

  • Kasikova, L., Hensler, M., Truxova, I. et al.. Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients. J Immunother Cancer, 2019. IN PRESS.
  • Truxova, I., Kasikova, L., Salek, C. et al. Calreticulin exposure on malignant blasts correlates with improved NK cell-mediated cytotoxicity in AML patients. Haematologica, 2019. IN PRESS.
  • Rodriguez-Ruiz, M.E., Buqué, A., Hensler, M. et al. Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients. Oncoimmunology, 2019. 8(11): p. e1655964.
  • Bravo-San Pedro, J.M., Sica, V., Martins, I. et al. Acyl-CoA-binding protein is a lipogenic factor that triggers food intake and obesity. Cell Metabol, 2019. 30(4): p. 754-767.e7.
  • Fucikova, J., Rakova, J., Hensler, M. et al. TIM-3 dictates functional orientation of the immune infiltrate in ovarian cancer. Clin Cancer Res, 2019. 25(15): p. 4820-4831.
  • Tatsuno, K., Yamazaki, T., Hanlon, D. et al. Extracorporeal photochemotherapy induces bona fide immunogenic cell death. Cell Death Dis, 2019. 29(10): p. 578.
  • Sica, V., Bravo-San Pedro, J.M., Izzo, V. et al. Lethal poisoning of cancer cells by respiratory chain inhibition plus dimethyl a-ketoglutarate. Cell Rep, 2019. 27(3): p. 820-834.e9.
  • Pabla, S., Conroy, J.M., Nesline, M.K. et al. Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients. J Immunother Cancer, 2019. 7(1): p. 27.
  • Conroy, J.M., Pabla, S., Nesline, M.K. et al. Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors. J Immunother Cancer, 2019. 7(1): p. 18.
  • Marchi, S., Corricelli, M., Branchini, A. et al. Akt-mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth. EMBO J, 2019. 38(2): p. e99435.
  • Truxova, I., Kasikova, L., Hensler, M. et al. Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients. J Immunother Cancer, 2018. 6(1): p. 139.
  • Morrison, C.D., Pabla, S., Conroy, J.M. et al. Predicting response to checkpoint inhibitors in melanoma beyond PD-L1 and mutational burden. J Immunother Cancer, 2018. 6(1): p. 32.
  • Bonora, M., Morganti. M., Morciano, G. et al. Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation. EMBO Rep, 2017. 18(7):1077-1089.
  • Fucikova, J., Truxova, I., Hensler, M. et al. Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients. Blood, 2016. 128(26): p. 3113-3124.

 
Review Articles 

  • Vanpouille-Box, C., Hoffmann, J.A. and L. Galluzzi. Pharmacological modulation of nucleic acid sensors - Therapeutic potential and persisting obstacles. Nat Rev Drug Discov, 2019. IN PRESS.
  • Deutsch, E., Chargary, C., Galluzzi, L. and G. Kroemer. Optimising efficacy and reducing toxicity of anticancer radioimmunotherapy. Lancet Oncol, 2019. 20(8): p. e452-e463.
  • Galluzzi, L., and D.R. Green. Autophagy-independent functions of the autophagy machinery. Cell, 2019. 177(7): p. 1682-1699.
  • Vitale, I., Manic, G., Coussens, L.M., et al. Macrophages and metabolism in the tumor microenvironment. Cell Metab, 2019. 30(1): p. 36-50.
  • Bonora, M., Wieckowski, M.W., Sinclair. D.A., et al. Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles. Nat Rev Cardiol, 2019. 16(1): p. 33-55.
  • Galluzzi, L., Yamazaki, T. and G. Kroemer. Linking intracellular adaptation to stress with organismal homeostasis. Nat Rev Mol Cell Biol, 2018. 19(11): p. 731-745.
  • Galluzzi, L., Chan, T., Kroemer, G. et al. The hallmarks of successful anticancer immunotherapy. Sci Transl Med, 2018. 10(459): p. eaat7807.
  • Vanpouille-Box, C., Demaria, S., Formenti, S.C. and L. Galluzzi. Cytosolic DNA sensing in organismal tumor control. Cancer Cell, 2018. 34(3): p. 361-378.
  • Galluzzi, L., Vanpouille-Box, C., Bakhoum, S.F. and S. Demaria. SnapShot: CGAS-STING signaling. Cell, 2018. 173(1): p. 276–276.e1.
  • Rybstein, M.D., Bravo-San Pedro, J.M., Kroemer G. and L. Galluzzi. The autophagic network and cancer. Nat Cell Biol, 2018. 20(3): p. 243-251.
  • Galluzzi, L., Vitale, I., Aaronson, S.A. et al. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ, 2018. 25(3): p. 486-541.
  • Carmona-Gutierrez, D., Bauer, M.A., Zimmermann, A., et al. Guidelines and recommendations on yeast cell death nomenclature. Microb Cell, 2018. 5(1): p. 4-31.
  • Bantug, G., Galluzzi, L., Kroemer, G., and C. Hess. The spectrum of T cell metabolism in health and disease. Nat Rev Immunol, 2018. 18(1): p. 19-34.
  • López-Soto, A., Gonzalez, S., Smyth, M.J. and L. Galluzzi. Control of metastases by NK cells. Cancer Cell, 2017. 32(2): p. 135-154.
  • Galluzzi, L., Baehrecke, E.H., Ballabio, A. et al. Molecular definitions of autophagy and related processes. EMBO J, 2017. 36(13): p. 1811-1836.
  • Galluzzi, L., Bravo-San Pedro, J.M., Levine, B., Green, D.R. and G. Kroemer. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat Rev Drug Discov, 2017. 16(7): p. 487-511. 
  • Vitale, I., Manic, G., De Maria, R., Kroemer, G. and L. Galluzzi. DNA damage in stem cells. Mol Cell, 2017. 66(3): p. 306-319.
  • Galluzzi, L., Bravo-San Pedro, J.M., Demaria, S., Formenti, S.C. and G. Kroemer. Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nat Rev Clin Oncol, 2017. 14(4): p. 247-258.
  • Galluzzi, L., Kepp, O., Chan, F.K. and G. Kroemer. Necroptosis: Mechanisms and relevance to disease. Annu Rev Pathol, 2017. 12: p. 103-130.
  • Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. and G. Kroemer. Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol, 2017. 17(2): p. 97-111.
  • López-Otín, C., Galluzzi, L., Freije, J.M.P., Madeo, F. and G. Kroemer. Metabolic control of longevity. Cell, 2016. 166(4): p. 802-821.
  • Galluzzi, L., Bravo-San Pedro, J.M., Blomgren, K. and G. Kroemer. Autophagy in acute brain injury. Nat Rev Neurosci, 2016. 17(8): p. 467-484.
  • Galluzzi, L., López-Soto, A., Kumar, S. and G. Kroemer. Caspases connect cell-death signaling to organismal homeostasis. Immunity, 2016. 44(2): p. 221-231.

 For a complete list of peer-reviewed publications from Lorenzo Galluzzi, please click here

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