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Radiation Oncology

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The Galluzzi Lab

The current interest of our team is to elucidate the links between cellular pathways of response to stress – including (but not limited to) autophagy, cellular senescence and multiple variants of regulated cell death – and the preservation of organismal homeostasis, with a particular focus on anticancer immunity. More specifically, we are interested in dissecting the complexity of the tumor microenvironment with respect to the mechanisms through which malignant as well as non-malignant components of the tumor exposed to chemotherapy, radiation therapy and immunotherapy emit danger signals that are involved in the initiation and perpetuation of robust immune responses. The detailed characterization of these molecular and cellular circuitries may identify stress-responsive mechanisms of adaptation in malignant or non-malignant cells as novel targets for the pharmacological manipulation of anticancer immune responses. Ultimately, these findings may translate into novel clinical studies based on combinatorial therapeutic regimens aimed at maximizing immunostimulation within the tumor microenvironment. 

Members:

Lorenzo Galluzzi, PhD

Principal Investigator

deadoc@vodafone.it

Lorenzo Galluzzi (born 1980) is currently Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College (New York, USA), and Honorary Associate Professor at the Faculty of Medicine of the Paris Descartes University (Paris, France).

Prior to joining Weill Cornell Medical College (2017), Lorenzo Galluzzi was a Junior Scientist of the Research Team “Apoptosis, Cancer and Immunity” at the Cordeliers Research Center (Paris, France; 2012-2016). Lorenzo Galluzzi did his post-doctoral training at the Gustave Roussy Cancer Center (Villejuif, France; 2009-2011), after receiving his PhD from the Paris Sud University (Le Kremlin-Bicetre, France; 2005-2008). He is also Associate Director of the European Academy for Tumor Immunology (EATI), and Founding Member of the European Research Institute for Integrated Cellular Pathology (ERI-ICP).

Lorenzo Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. In particular, he provided profound insights into the links between adaptive stress responses in cancer cells and the activation of a clinically relevant tumor-targeting immune response in the context of chemotherapy and radiation therapy. Lorenzo Galluzzi has published more than 350 scientific articles in international peer-reviewed journals. According to a survey published by Lab Times, he is currently the 6th and the youngest of the 30 most-cited European cell biologists (relative to the period 2007–2013).

Takahiro Yamakazi, PhD

Post-Doctoral Fellow

tay2007@med.cornell.edu

Aitziber Buqué Martinez, PhD

Post-Doctoral Fellow

abuquemartinez@gmail.com

Jonathan J. Chen, MD

Radiation Oncology Resident

joc2037@nyp.org

Marissa D. Rybstein, MD, MHA

Medical Oncology Fellow

mdf9007@nyp.org

 

Recent Publications 

  • Galluzzi, L., Vanpouille-Box, C., Bakhoum, S.F. and S. Demaria. SnapShot: CGAS-STING signalingCell, 2018. 173(1): p. 276–276.e1.
  • Rybstein, M.D., Bravo-San Pedro, J.M., Kroemer G. and L. GalluzziThe autophagic network and cancerNat Cell Biol, 2018. 20(3): p. 243-251.
  • Galluzzi, L., Vitale, I., Aaronson, S.A. et al. Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018Cell Death Differ, 2018. 25(3): p. 486-541.
  • Carmona-Gutierrez, D., Bauer, M.A., Zimmermann, A., et al. Guidelines and recommendations of yeast cell death nomenclature. Microb Cell, 2018. 5(1):p. 4-31.
  • Bantug, G., Galluzzi, L., Kroemer, G., and C. Hess. The spectrum of T cell metabolism in health and diseaseNat Rev Immunol, 2018. 18(1): p. 19-34.
  • López-Soto, A., Gonzalez, S., Smyth, M.J. and L. Galluzzi. Control of metastases by NK cells. Cancer Cell, 2017. 32(2): p. 135-154.
  • Galluzzi, L., Baehrecke, E.H., Ballabio, A. et al. Molecular definitions of autophagy and related processesEMBO J, 2017. 36(13): p. 1811-1836.
  • Galluzzi, L., Bravo-San Pedro, J.M., Levine, B., Green, D.R. and G. Kroemer. Pharmacological modulation of autophagy: therapeutic potential and persisting obstaclesNat Rev Drug Discov, 2017. 16(7): p. 487-511.
  • Vitale, I., Manic, G., De Maria, R., Kroemer, G. and L. GalluzziDNA damage in stem cellsMol Cell, 2017. 66(3): p. 306-319.
  • Galluzzi, L., Bravo-San Pedro, J.M., Demaria, S., Formenti, S.C. and G. Kroemer. Activating autophagy to potentiate immunogenic chemotherapy and radiation therapyNat Rev Clin Oncol, 2017. 14(4): p. 247-258.
  • Galluzzi, L., Kepp, O., Chan, F.K. and G. Kroemer. Necroptosis: Mechanisms and relevance to diseaseAnnu Rev Pathol, 2017. 12: p. 103-130.
  • Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L. and G. Kroemer. Immunogenic cell death in cancer and infectious diseaseNat Rev Immunol, 2017. 17(2): p. 97-111.
  • López-Otín, C., Galluzzi, L., Freije, J.M.P., Madeo, F. and G. Kroemer. Metabolic control of longevityCell, 2016. 166(4): p. 802-821.
  • Galluzzi, L., Bravo-San Pedro, J.M., Blomgren, K. and G. Kroemer. Autophagy in acute brain injuryNat Rev Neurosci, 2016. 17(8): p. 467-484.
  • Galluzzi, L., López-Soto, A., Kumar, S. and G. Kroemer. Caspases connect cell-death signaling to organismal homeostasisImmunity, 2016. 44(2): p. 221-231.

 

For a complete list of peer-reviewed publications from Lorenzo Galluzzi, please click here

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Stich Radiation Oncology Center

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